Figure 1.

Short-term incretin therapy improves glucose tolerance. (a) Timing of short-term diabetes therapy (glipizide, exenatide, des-fluoro-sitagliptin, or vehicle [control]), GTT, and kill (SAC) in 10-week-old B6.129 F1 hybrid mice. (b) Initial and final body weight (in grams). (c) Intraperitoneal GTT was performed, with the corresponding area under the curve analysis in (d). (e and f) Fasting and random-fed serum insulin (ng/mL). Means ± standard error of the mean (n = 5 animals/group). **P < 0.01.