Figure 3.

Short-term incretin therapy (Tx) does not expand β-cells. (a–d) Total pancreas (green) and total β-cell area (red) generated by composites of low-power image scans from pancreatic sections of short-term treated mice with (a) vehicle (control), (b) glipizide, (c) exenatide, or (d) des-fluoro-sitagliptin. Scale bar, 2 mm. (e) β-cell area (% total) and (f) β-cell mass (in milligrams) for the head, tail, and total pancreas. Mean ± standard error of the mean (21–28 sections/pancreas; n = 5 animals/group).