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. 2017 Jun 5;149(6):661–680. doi: 10.1085/jgp.201711762

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© 2017 Amin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 5. — Single-channel recordings of wild-type NMDARs and NMDARs with tryptophan substitutions that showed significantly reduced whole-cell current amplitudes. (A) Example single-channel recordings of GluN1/GluN2A, GluN1(M813W)/GluN2A, or GluN1(E834W)/GluN2A. Recordings were performed in the cell-attached configuration with a pipette potential of 100 mV. Downward deflections reflect inward currents. For each construct, the top half shows a low-resolution example (filtered at 1 kHz), and the bottom half shows a higher-resolution portion of the same record (filtered at 3 kHz). (B) Single-channel current amplitudes (top) and equilibrium open probability (eq. P_o; bottom) shown as mean ± SEM (Table 3). Solid bars indicate values significantly different from wild type (P < 0.05, t test). (C) Approximate number of ion channels in the membrane mediating steady-state whole-cell current amplitudes (Table 4).