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. 2017 Jun 5;149(6):661–680. doi: 10.1085/jgp.201711762

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© 2017 Amin et al.

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Figure 8. — Substitutions of the VVLGAVE face in GluA2 have no or only weak effects on receptor desensitization. (A) Example outside-out recordings from wild-type GluA2(Q)-EGFP (top trace) or V816I (bottom trace) in response to 100-ms pulses of glutamate. (B) Mean (±SEM) %Des (left) and rate of desensitization (right). Black bars indicate values significantly different from wild type (P < 0.05, t test). Many of the tested positions had strong effects on receptor tetramerization (Fig. 2). We also tested GluA2(L832W), a position on the side of the helix facing away from the pore domain. Number of outside-out patches for each construct: wt, 9; V813I, 4; V816I, 4; L820F, 5; G823A, 4; A827S, 4; V830L, 4; L832W, 4; E834Q, 4; E834D, 4; E834N, 3.