FIG. 1.
Illustration of different TBs that coordinate the PK profiles in terms of day and evening child activities. The three black outlined boxes illustrate day TB (TBD) divided into an AM box (TBD1) and a PM box (TBD2) and evening TB (TBE). Arrows from left to right refer to the following: 
, 
. 
[
, 
]. For the 
, 
ng/mL, 
ng/mL. For the AM period, 
am and 
pm. For the PM period, 
pm and 
pm. For the 
pm, 
pm and 
. The thick gray bar shows the range of the first administration time (noted T), from 
am and 
am. TB: therapeutic boxes; 
day therapeutic box during AM period; 
day therapeutic box during PM period; 
evening therapeutic box; 
minimum effective concentration in day therapeutic box; 
maximum concentration in day therapeutic box; 
minimum concentration in evening therapeutic box; 
maximum concentration in evening therapeutic box; ts: starting administration time of T period; te: ending administration time of T period; 
starting time of day therapeutic box in AM period; 
ending time of day therapeutic box in AM period; 
starting time of day therapeutic box in PM period; 
ending time of day therapeutic box in PM period; 
starting time of evening therapeutic box; 
ending time of evening therapeutic box; PK: pharmacokinetic.