Table 4.
Comparison of the TIs (±SD) and the Performance (±SD) Between Optimal TID Regimen (Last Regimen) and Regimens Defined in MTA Study for 1000 Patients with 1000 Iterations
| Doses (mg) | Times (h) |
 (%)
|
 (%)
|
 (%)
|
 (%)
|
 (%)
|
 (%)
|
Performance (%) |
|---|---|---|---|---|---|---|---|---|
| 5, 5, 5 | 7, 11, 14 | 13.9 (±0.7) | 35.2 (±1.2) | 98.3 (±0.3) | 3.2 (±0.6) | 21.1 (±1.3) | 97.3 (±0.5) | 44.8 (±0.5) |
| [7,8], [11,12], [15,16] | [6.6 ± 0.6: 16.7 ± 0.7] | [18.8 ± 0.9, 37.3 ± 1.3] | [91.8 ± 0.7, 96.8 ± 0.5] | [1 ± 0.3, 3.4 ± 0.6] | [5.5 ± 0.7, 25.2 ± 1.4] | [87.6 ± 1, 95 ± 0.7] | [37.2 ± 0.2, 43.3 ± 0.4] | |
| 10, 10, 5 | 7, 11, 14 | 58.1 (±1.1) | 76.6 (±0.9) | 96.3 (±0.5) | 35.1 (±1.5) | 61.1 (±1.6) | 93.8 (±0.7) | 70.2 (±0.7) |
| [7,8], [11,12], [15,16] | [44.1 ± 1.1, 58.5 ± 1] | [60.8 ± 1.1, 81.7 ± 0.9] | [82.3 ± 0.9, 93.8 ± 0.6] | [21 ± 1.3, 35.5 ± 1.5] | [39.9 ± 1.6, 70.9 ± 1.5] | [72.5 ± 1.4, 89.7 ± 0.9] | [58.3 ± 0.6, 67.3 ± 0.8] | |
| 15, 15, 5 | 7, 11, 14 | 75.5 (±0.9) | 83.8 (±0.8) | 87.9 (±0.9) | 53.6 (±1.6) | 72.2 (±1.5) | 81.3 (±1.2) | 75.7 (±0.9) |
| [7,8], [11,12], [15,16] | [66.1 ± 0.7, 75.7 ± 0.9) | [78 ± 0.9, 84.1 ± 0.9] | [64.3 ± 1.2, 83.4 ± 0.9] | [33.4 ± 1.5, 53.9 ± 1.6] | [60.4 ± 1.6, 73.2 ± 1.4] | [49.8 ± 1.6, 74.6 ± 1.3] | [62.1 ± 0.8, 73.7 ± 0.9] | |
| 20, 20, 10 | 7, 11, 14 | 71.9 (±0.9) | 68.1 (±1.1) | 55 (±1.3) | 47.1 (±1.5) | 52.2 (±1.6) | 39.5 (±1.6) | 55 (±1.1) |
| [7,8], [11,12], [15,16] | [59.4 ± 0.8, 76.4 ± 0.8] | [60.2 ± 1.2, 74.9 ± 0.9] | [20 ± 1, 42.8 ± 1.3] | [24.8 ± 1.4, 56.5 ± 1.6] | [44.1 ± 1.5, 58.1 ± 1.6] | [8.7 ± 0.9, 26.8 ± 1.4] | [41.3 ± 0.8, 53.3 ± 1] | |
| 20, 10, 5 | 7,11,14 | 81.3 (±0.8) | 90.5 (±0.5) | 94.9 (±0.5) | 66.5 (±1.5) | 83.1 (±1.2) | 91 (±0.9) | 84.6 (±0.6) |
In italic, performance below 60%; In bold, performance between 60 and 80%; Underlined, performance ≥80%.
TIs: therapeutic indicators; SD, standard deviation; 
therapeutic indicator of effective time into day therapeutic box for AM period; 
therapeutic indicator of effective time into day therapeutic box for PM period; 
therapeutic indicator of effective time into evening therapeutic box; 
therapeutic indicator responders into day therapeutic box for AM period; 
therapeutic indicator responders into day therapeutic box for PM period; 
therapeutic indicator responders into evening therapeutic box; 
therapeutic indicator of roller coaster effect; all TIs are in percentage; [xmin ± SDxmin, xmax ± SDxmax] correspond to the minimum value with its SD and maximum value with its SD of TI of MTA regimens, respectively.