. Author manuscript; available in PMC: 2017 Jun 6.

Published in final edited form as: Environ Sci Technol. 2016 Dec 20;51(1):625–633. doi: 10.1021/acs.est.6b04374

Table 2.

Beta and p-Values for the Cord Serum Metabolites Identified by Multivariable Linear Regression Models^a as Having a Significant Association with Either Total Urinary iAs (ln U-tAs) or Percentages of Urinary iAs Metabolites (U-%iAs, U-%MMAs, U-%DMAs) and Associations with Either Total Cord Serum iAs (ln C-tAs) or Percentages of Cord Serum iAs Metabolites (C-% iAs, C-%MMAs, C-%DMAs)

metabolite	maternal urinary arsenicals
metabolite	U-tAs β (p-value) [FDR p-value]	U-%iAs β (p-value) [FDR p-value]	U-%MMAs β (p-value) [FDR p-value]	U-%DMAs β (p-value) [FDR p-value]
glutamate	−0.01 (0.09) [0.14]	0.005 (0.01)^b [0.10]	0.003 (0.1) [0.12]	−0.003 (0.03)^b [0.066]
glycine	0.005 (0.5) [0.5]	0.004 (0.09) [0.22]	0.004 (0.07) [0.11]	−0.003 (0.03)^b [0.066]
methionine	−0.0009 (0.1) [0.14]	0.0004 (0.05)^b [0.16]	0.0005 (0.01)^b [0.05]	−0.0003 (0.01)^b [0.066]
O-acetylcholine	−0.003 (0.04)^b [0.10]	0.0009 (0.05)^b [0.16]	0.0009 (0.06) [0.11]	−0.0006 (0.02)^b [0.066]
isoleucine	−0.003 (0.01)^b [0.10]	0.02 (0.4) [0.57]	0.0008 (0.01)^b [0.05]	−0.0002 (0.3) [0.41]
taurine	−0.002 (0.3) [0.33]	0.0007 (0.2) [0.33]	0.001 (0.04)^b [0.10]	−0.0006 (0.06) [0.11]
valine	−0.004 (0.3) [0.33]	−0.0003 (0.7) [0.77]	0.002 (0.02)^b [0.066]	−0.0007 (0.2) [0.31]
succinate	0.002 (0.05)^b [0.10]	0 (0.9) [0.9]	−0.0001 (0.7) [0.77]	0 (0.9) [0.90]
mannose	0.005 (0.02)^b [0.10]	−0.0004 (0.5) [0.62]	0 (0.9) [0.90]	0.01 (0.8) [0.88]
tyrosine	−0.001 (0.03)^b [0.10]	0.0002 (0.2) [0.33]	0.0003 (0.1) [0.12]	0.0002 (0.08) [0.18]

metabolite	neonate cord serum arsenicals
metabolite	C-tAs β (p-value) [FDR p-value]	C-%iAs β (p-value) [FDR p-value]	C-%MMAs β (p-value) [FDR p-value]	C-%DMAs β (p-value) [FDR p-value]

acetoacetate	0.0003 (0.9) [0.9]	0.0004 (0.02)^b [0.1]	0.0002 (0.01)^b [0.04]	−0.0004 (0.01)^b [0.05]
acetone	0.003 (0.2) [0.4]	0.0003 (0.03)^b [0.1]	0.0002 (0.5) [0.6]	−0.0004 (0.002)^b [0.02]
betaine	−0.003(0.2) [0.4]	−0.0001 (0.7) [0.7]	0.004 (0.004)^b [0.01]	0.0002 (0.2) [0.5]
ethanol	0.02 (0.4) [0.7]	0.004 (0.007)^b [0.06]	−0.007 (0.09) [0.1]	−0.003 (0.06) [0.2]
glutamate	−0.02 (0.02)^b [0.08]	−0.0005 (0.3) [0.6]	0.002 (0.1) [0.1]	0.0001 (0.7) [0.7]
glycerol	0.004 (0.2) [0.4]	0 (0.9) [0.9]	0.002 (0.0003)^b [0.1]	−0.0003 (0.1) [0.4]
glycine	0.01 (0.1) [0.3]	−0.0004 (0.4) [0.7]	0.005 (<0.001)^b [0.001]	−0.0005 (0.3) [0.6]
isoleucine	−0.003 (0.03)^b [0.08]	−0.0001 (0.5) [0.7]	0.0001 (0.5) [0.6]	0 (0.7) [0.7]
lactate	0.02 (0.9) [0.9]	−0.005 (0.5) [0.7]	0.04 (0.02)^b [0.05]	−0.003 (0.7) [0.7]
mannose	0.006 (0.02)^b [0.08]	−0.0001 (0.3) [0.6]	0.001 (0.001)^b [0.005]	−0.0001 (0.6) [0.7]
methionine	−0.002 (0.02)^b [0.08]	0 (0.4) [0.6]	0 (0.9) [0.9]	0 (0.4) [0.6]
O-acetylcholine	−0.004 (0.03)^b [0.08]	−0.0002 (0.1) [0.2]	0.0001 (0.7) [0.7]	0.0002 (0.1) [0.4]
pyruvate	0.0005 (0.8) [0.9]	−0.0001 (0.6) [0.7]	0.001 (0.001)^b [0.005]	−0.0001 (0.4) [0.6]
serine	−0.0006 (0.8) [0.9]	0 (0.8) [0.9]	0.001 (0.027)^b [0.05]	−0.0002 (0.4) [0.6]
taurine	−0.0005 (0.8) [0.9]	−0.0001 (0.4) [0.6]	0.0009 (0.001)^b [0.005]	−0.0001 (0.6) [0.7]
tyrosine	−0.002 (0.01)^b [0.08]	−0.0001 (0.01)^b [0.1]	0.0002 (0.03)^b [0.05]	0.0001 (0.1) [0.4]
3-hydroxybutyrate	0.04 (0.7) [0.9]	0.002 (0.007)^b [0.06]	0.001 (0.4) [0.5]	−0.002 (0.001)^b [0.02]

All models adjusted for maternal age, gender of the infant, and gestational age.

FDR ≤ 0.1.