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. 2017 Jun 5;214(6):1787–1808. doi: 10.1084/jem.20160553

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© 2017 Miao et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 7. — Egr2 and 3 regulated genes are important for early proliferation of T cells in response to infection. (A) Volcano plots of the entire RNA-seq dataset (gray) were overlaid with the indicated functional groups of genes (colors) previously defined in CD8 T cells at different stages of infection (Best et al., 2013), with positive and negative log2 fold changes indicating higher expression in GFP-Egr2 and CD2-Egr2/3^−/− (K2-3) cells, respectively. (B) Key genes differentially expressed between GFP-Egr2 and K2-3 cells in the RNA-seq dataset show similar patterns in both CD44^highGFP-Egr2^highCD8⁺ and CD44^highGFP-Egr2^lowCD8⁺ cells from GFP-Egr2 knock-in mice (top) and CD8⁺Kb-SIINFEKL-tetramer⁺ cells from WT and CD2-Egr2/3^−/− mice (bottom) 7 d after infection with OVA-VV_WR. Data are means ± SD and are representative of three independent experiments (each with n = 10 mice/group).