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. 2017 Jun 5;214(6):1643–1653. doi: 10.1084/jem.20160923

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© 2017 Xu et al.

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Figure 3. — Hematopoietic but not endothelial deletion of Etv2 impairs HSPC recovery after 5-FU treatment. (A–I) Tie2-Cre;Etv2 CKO, VEC-Cre;Etv2 CKO, Vav-Cre;Etv2 CKO, or littermate control mice were injected with 250 mg/kg 5-FU i.p. After 11 d, BM mononuclear cells were subjected to flow cytometry by using HSPC surface markers to determine absolute cell number (per femur and tibia) of different hematopoietic compartments. (A) Lin⁻ cells. (B) KSL (c-Kit⁺Sca1⁺Lin⁻) cells. (C) Long-term HSCs (CD34⁻Flt3⁻ KSL). (D) Short-term HSCs (CD34⁺Flt3⁻ KSL). (E) Multipotent progenitor (CD34⁺Flt3⁺ KSL) cells. (F) LK (c-Kit⁺Sca1⁻Lin⁻) cells. (G) Common myeloid progenitor (CMP; CD34⁺CD16/32⁻ LK) cells. (H) Granulocyte-macrophage progenitor (GMP; CD34⁺CD16/32⁺ LK) cells. (I) Megakaryocyte-erythrocyte progenitor (MEP; CD34⁻CD16/32⁻ LK) cells. n = 4–6 from two independent experiments. *, P < 0.05; **, P < 0.001. Error bars indicate standard error of the mean.