Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 5;214(6):1843–1855. doi: 10.1084/jem.20170015

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Xia et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — RNF8/UbcH8-mediated histone H3 polyubiquitylation and degradation promotes gene expression. EGFR activation results in PKM2 phosphorylating H3 at T11 and subsequent binding of RNF8 FHA domain to phosphorylated histone H3. RNF8-mediated H3-K4 polyubiquitylation promotes the dissociation of histone from chromatin, degradation of histones, and binding of RNA polymerase (Pol) II for gene transcription of MYC and CCND1, which promotes the glycolysis, cell proliferation, and tumorigenesis.