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. 2017 Jun 5;214(6):1564–1566. doi: 10.1084/jem.20170842

graphic file with name JEM_20170842_Fig2.jpg

(A) TRM cells are enriched in the HBV-infected liver, and their frequency correlates inversely with HBV titer. (B) CD8+ TRM cells reside in the liver sinusoids. They express the tissue-homing marker CD69, and a subset additionally expresses the integrin CD103. TRM cells display a unique transcriptional profile (T-betlo, Eomeslo, Notchhi). Despite high expression levels of the inhibitory receptor PD-1, they readily produce antiviral cytokines upon in vitro stimulation.