Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 5;216(6):1833–1847. doi: 10.1083/jcb.201611057

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Tang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Working model for RSC lineage specification. Fast-cycling bipotent cells (BPs; in blue) of the ML in developing optic vesicles migrate and proliferate into one PP (in black) and one SP (in red) between 18 and 26 hpf. Subsequently, slow-cycling SPs proliferate and produce three types of lineages, including two asymmetric lineage types and one symmetric lineage type. Two asymmetric lineages were composed of one RSC (S; in red) and one dormant CMZ tip cell (D; in black/red; 60% of total RSC-generating lineages) or one RSC and a retinal progenitor (RP; in red; 38%). One symmetric lineage contained two RSCs (in red; 2%). Meanwhile, PPs proliferated and produced two types of lineages, including the lineages of two pigmented cells (Ps; in black; 64%) and the lineages of one pigmented cell (in black) and one CMZ dormant tip cell (36%). Note that dormant CMZ tip cells are produced by both PPs and SPs.