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. 2017 Jun 5;216(6):1715–1730. doi: 10.1083/jcb.201612123

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© 2017 Wang et al.

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Figure 4. — LysoK_VCa is preferentially expressed in the lysosome. (A) Step currents of Lyso-SLO1 (left) and Lyso-SLO1+ β2 (right) in the presence of 100 µM Ca²⁺. (B) Localization of β2-GFP in the Lamp1-positive compartments. Bar, 10 µm. (C) Whole-cell K⁺ currents sensitive to paxilline (1 µM) in nontransfected Cos-1 cells. The pipette solution contained 100 µM Ca²⁺. (D) Densities (mean ± SEM) of plasma membrane BK-like currents vs. LysoK_VCa in Cos-1 cells and MEFs. Statistical comparisons were made with variance analysis (Student’s t test). ***, P < 0.001.