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. 2017 Jun 5;216(6):1579–1596. doi: 10.1083/jcb.201701165

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© 2017 Malinová et al.

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Figure 10. — Model for the assembly of U5-specific proteins. The HSP90/R2TP chaperone recruits PRPF8 and EFTUD2 rapidly after their synthesis and promotes the formation of a cytoplasmic assembly intermediate complex containing AAR2, ZNHIT2, and possibly other factors. This complex translocates to the nucleus and binds SNRNP200. AAR2 is released upon binding of U5 snRNA, and maturation is complete after the release of ZNHIT2 and R2TP proteins.