Table 3.

Incidence (%) of most frequent adverse drug reactions

Most frequent adverse events	Placebo-controlled studies		Cinacalcet-controlled studies
	Placebo n=513	Etelcalcetide n=503	Cinacalcet n=341	Etelcalcetide n=338
Diarrhea	8.6	10.7	10.3	6.2
Nausea	6.2	10.7	22.6	18.3
Vomiting	5.1	8.9	13.8	13.3
Calcium reduction	10.1	63.8	59.8	68.9
Hypocalcemiaa	0.2	7.0	2.3	5.0
Hyperkalemia	3.1	4.4	5.3	3.8
Muscle spasms	6.6	11.5	5.9	6.5
Paraesthesia	1.2	6.2	2.6	3.3
Hypotension	–	–	2.9	6.8

Note:

^aHypocalcemia definition: symptomatic reduction in serum corrected calcium <8.3 mg/dL.