Table 2.
Peptide characteristics
| Peptide no. | Sequence | Location in H77* | Protein |
|---|---|---|---|
| 1 | YEVRNVSGIYHVTNDCSNS | 192 − 210 | E1 |
| 2 | SSGLYHVTNDC | 197 − 207 | E1 |
| 3 | SIVYEAA | 211 − 217 | E1 |
| 4 | RHWTTQGCNC | 297 − 306 | E1 |
| 5 | SGHRMAWDMMMNWSPTT | 314 − 330 | E1 |
| 6 | ETHVTGGS | 384 − 391 | E2 |
| 7 | TAGLVGLLTPGA | 396 − 407 | E2 |
| 8 | SQKIQLVNTNGSWHIN | 408 − 423 | E2 |
| 9 | GSWHINRTALNCND | 418 − 431 | E2 |
| 10 | SLNTGWLAGLFYQHKF | 432 − 447 | E2 |
| 11 | DFDQGWGPISYA | 464 − 475 | E2 |
| 12 | IVPAKSVCGPVYCFTPSPVV | 496 − 515 | E2 |
| 13 | SGAPTYSWGA | 522 − 531 | E2 |
| 14 | PPLGNWFG | 544 − 551 | E2 |
| 15 | YRLWHYPCT | 613 − 621 | E2 |
| 16 | LDAACNWTRGERCD | 640 − 653 | E2 |
| 17 | RGERCDLEDRDR | 648 − 659 | E2 |
A total of 17 linear peptides were reported to be recognized by defined anti‐hepatitis C virus (HCV) E1/E2 monoclonal antibodies. Underlined epitopes 1 11, 5 12, 13, 7 14, 8 15, 16, 10 17 and 12 18, 19 are overlapped with six putative linear neutralizing epitopes, and the other 11 epitopes (2, 3, 4, 6, 9, 11, 13, 14, 15, 16 and 17) are targets recognized by well‐characterized anti‐HCV E1/E2 monoclonal antibodies 20, 21, 22, 23, 24, 25. *The first and final positions are numbered with reference to the consensus sequence of the polyprotein of HCV strain H77 (Genbank accession number AB009606).