Table 1.

Description of CTN studies

CTN Study Number	Study Title	Years	Sample Size	Arm (T vs. C)	Example of Eligibility Criteria
Buprenorphine/naloxone (Bup/Nx) detoxification
CTN0001	Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Inpatient Opiate Detoxification	2001–2002	113	Bup/Nx vs.Clonidine	Inpatient treatment-seeking males and non-pregnant and non-lactating females, 15 years and older, with DSM-IV opiate dependence
CTN0002	Buprenorphine/Naloxone (Bup/Nx) versus Clonidine for Outpatient Opiate Detoxification	2001–2002	230	Bup/Nx vs.Clonidine	Outpatient treatment-seeking males and non-pregnant and non-lactating females, 15 years and older, with DSM-IV opiate dependence
CTN0003	Suboxone® (Bup/Nx) Taper: A Comparison of Two Schedules	2003–2005	516	7-day vs. 28-day Bup/Nx Taper	Outpatient treatment-seeking males and non-pregnant and non-lactating females, 15 years and older, with DSM-IV opiate dependence
CTN00010	Buprenorphine/Naloxone (Bup/Nx) Facilitated Rehabilitation for Heroin Addicted Adolescents/Young Adults	2003–2006	154	Bup/Nx vs. Detox	Outpatient treatment-seeking males and non-pregnant and non-lactating females, 14–21 years old, with DSM-IV-TR opiate dependence
CTN00030	Buprenorphine/Naloxone Treatment Plus Individual Drug Counseling for Opioid Analgesic Dependence	2006–2009	653	Bup/Nx + Counseling vs. Bup/Nx	Outpatient treatment-seeking males and non-pregnant and non-lactating females, 18 years and older, with DSM-IV opiate dependence
Motivational enhancement/interviewing (MEI)
CTN0004	Motivational Enhancement Treatment (MET) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse	2001–2004	461	MET vs. Counseling as usual (CAU)	Outpatient treatment-seeking individuals for any substance use disorder with use of any substance in the past 28 days, 18 years and older
CTN0005	Motivational Interviewing (MI) To Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse	2001–2002	423	MI vs. treatment-as-usual (TAU)	Outpatient treatment-seeking individuals for any substance use disorder with use of any substance in the past 28 days, 18 years and older
CTN0013	Motivational Enhancement Therapy (MET) to Improve Treatment Utilization and Outcome in Pregnant Substance Users	2003–2006	200	MET vs. TAU	Pregnant women (Less than 32 weeks), identified as needing substance abuse treatment, 18 years and older
Motivational incentives (Incentives)
CTN0006	Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics	2001–2003	454	Incentives vs. TAU	Outpatient treatment-seeking individuals with evidence of cocaine or methamphetamine use, without gambling problems
CTN0007	Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics	2001–2003	388	Incentives vs. TAU	Outpatient treatment-seeking individuals with evidence of cocaine or methamphetamine use, without gambling problems