Table 1.
Baseline characteristics of the participants according to extreme tertiles of thyroid hormones
| Free T3 (pg/mL) | Total T3 (ng/mL) | Free T4 (pmol/mL) | Total T4 (nmol/mL) | TSH (mIU/L) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Tertile 1 <3.04 |
Tertile 3 >3.34 |
Tertile 1 <104.2 |
Tertile 3 >119.9 |
Tertile 1 <14.1 |
Tertile 3 >15.8 |
Tertile 1 <77.4 |
Tertile 3 >89.5 |
Tertile 1 <1.27 |
Tertile 3 >2.0 |
|
| N | 178 | 181 | 175 | 175 | 187 | 186 | 174 | 174 | 182 | 185 |
| Age (years) | 52.4 ± 8.6 | 50.8 ± 9.6 | 52.8 ± 8.5 | 51.0 ± 9.2 | 51.4 ± 8.8 | 51.5 ± 9.6 | 52.1 ± 8.6 | 50.9 ± 9.8 | 51.0 ± 9.4 | 52.4 ± 8.5 |
| Sex, men, % | 16.9 | 61.3 | 30.9 | 40.6 | 27.8 | 45.7 | 44.3 | 27.6 | 39.0 | 35.1 |
| Race, White, % | 76.4 | 88.4 | 81.1 | 81.1 | 75.9 | 84.9 | 82.2 | 81.0 | 73.6 | 87.0 |
| BMI (kg/m2) | 31.9 ± 4.0 | 33.4 ± 3.5 | 31.7 ± 3.8 | 33.5 ± 3.6 | 32.9 ± 4.0 | 32.5 ± 3.7 | 32.3 ± 3.8 | 32.5 ± 3.8 | 32.7 ± 3.8 | 32.8 ± 3.8 |
| Weight (kg) | 87.8 ± 15.1 | 98.3 ± 14.6 | 89.4 ± 15.2 | 95.5 ± 14.4 | 92.5 ± 16.2 | 93.2 ± 15.3 | 93.6 ± 16.0 | 91.5 ± 14.7 | 92.7 ± 15.6 | 93.2 ± 15.3 |
| Waist circumference (cm) | 98.4 ± 13.1 | 108.6 ± 11.7 | 100.1 ± 12.8 | 106.6 ± 12.1 | 102.7 ± 13.9 | 104.1 ± 12.3 | 103.8 ± 13.6 | 102.8 ± 12.2 | 104.0 ± 12.8 | 103.8 ± 13.3 |
| Resting metabolic rate (kcal/24h) | 1406 ± 260 | 1699 ± 303 | 1468 ± 295 | 1612 ± 295 | 1519 ± 303 | 1563 ± 300 | 1575 ± 324 | 1501 ± 260 | 1559 ± 310 | 1538 ± 292 |
| Education level, some college, % | 18.0 | 18.2 | 17.1 | 21.7 | 19.3 | 17.2 | 17.8 | 20.1 | 19.8 | 17.3 |
| Current smoker, yes, % | 3.4 | 4.4 | 1.7 | 3.4 | 2.7 | 1.6 | 2.9 | 2.3 | 3.3 | 2.7 |
| Alcohol consumption (drinks/week) | 2.4 ± 3.4 | 2.2 ± 2.9 | 3.0 ± 3.8 | 1.8 ± 2.7 | 2.3 ± 3.4 | 2.1 ± 2.7 | 3.1 ± 3.8 | 1.2 ± 1.9 | 2.3 ± 3.3 | 2.0 ± 2.8 |
| Physical activity | 1.58 ± 0.1 | 1.57 ± 0.1 | 1.60 ± 0.1 | 1.56 ± 0.1 | 1.57 ± 0.1 | 1.59 ± 0.1 | 1.59 ± 0.1 | 1.56 ± 0.1 | 1.58 ± 0.1 | 1.57 ± 0.1 |
| Systolic blood pressure (mmHg) | 117.4 ± 13.1 | 122.1 ± 12.1 | 119.0 ± 13.9 | 122.4 ± 13.6 | 119.8 ± 13.5 | 119.4 ± 12.0 | 119.7 ± 12.6 | 118.9 ± 12.6 | 120.2 ± 14.2 | 120.3 ± 14.0 |
| Diastolic blood pressure (mmHg) | 73.3 ± 8.7 | 77.7 ± 8.9 | 74.0 ± 9.3 | 78.2 ± 9.1 | 75.4 ± 9.4 | 76.0 ± 8.6 | 74.9 ± 9.1 | 75.7 ± 8.0 | 75.9 ± 9.6 | 75.7 ± 9.0 |
| Total fat mass (kg) * | 34.7 ± 7.7 | 35.1 ± 7.5 | 33.5 ± 8.0 | 36.4 ± 7.0 | 35.5 ± 8.2 | 34.9 ± 7.7 | 33.6 ± 7.7 | 35.8 ± 7.4 | 34.9 ± 7.9 | 35.7 ± 7.4 |
| Total lean mass (kg) * | 53.9 ± 11.5 | 64.8 ± 12.9 | 57.7 ± 12.0 | 60.5 ± 13.3 | 59.5 ± 13.5 | 60.1 ± 13.6 | 63.1 ± 13.5 | 57.0 ± 12.4 | 60.4 ± 13.6 | 60.4 ± 13.8 |
| Glucose (mg/dL) | 90.5 ± 11.6 | 93.8 ± 12.9 | 91.9 ± 12.2 | 93.4 ± 12.7 | 93.6 ± 13.4 | 92.3 ± 12.1 | 93.4 ± 12.1 | 91.0 ± 11.6 | 92.4 ± 12.5 | 93.3 ± 13.4 |
| Insulin (uU/mL) | 10.0 ± 6.2 | 15.0 ± 9.8 | 9.7 ± 5.5 | 14.9 ± 9.4 | 13.7 ± 9.4 | 11.4 ± 6.3 | 12.2 ± 8.9 | 12.7 ± 7.8 | 13.2 ± 9.7 | 12.1 ± 6.6 |
| Total cholesterol (mg/dL) | 245.0 ± 87.0 | 264.9 ± 121.8 | 249.4 ± 96.3 | 262.8 ± 113.7 | 265.0 ± 125.2 | 240.2 ± 90.7 | 256.9 ± 120.5 | 250.0 ± 99.0 | 250.9 ± 97.4 | 252.8 ± 108.5 |
| LDL cholesterol (mg/dL) | 129.7 ± 30.5 | 120.3 ± 32.5 | 128.4 ± 30.7 | 120.4 ± 31.8 | 127.4 ± 33.1 | 123.8 ± 30.6 | 123.4 ± 32.2 | 123.4 ± 30.2 | 122.0 ± 31.3 | 122.7 ± 29.4 |
| HDL cholesterol (mg/dL) | 54.4 ± 14.2 | 43.6 ± 12.1 | 52.3 ± 14.6 | 46.6 ± 13.5 | 49.9 ± 14.5 | 48.4 ± 14.0 | 48.1 ± 13.8 | 49.3 ± 13.8 | 48.3 ± 14.1 | 49.3 ± 13.8 |
| Triglycerides (mg/dL) | 124.9 ± 72.8 | 169.6 ± 93.0 | 124.5 ± 63.6 | 161.4 ± 94.1 | 149.1 ± 88.4 | 140.1 ± 73.3 | 142.4 ± 77.2 | 147.2 ± 83.0 | 138.7 ± 72.8 | 153.4 ± 91.1 |
| Leptin (ng/mL) | 31.3 ± 18.1 | 25.9 ± 18.9 | 25.9 ± 17.4 | 32.2 ± 20.1 | 32.8 ± 19.7 | 25.1 ± 17.5 | 25.5 ± 18.0 | 31.6 ± 19.0 | 27.8 ± 19.7 | 30.1 ± 18.2 |
| Leptin soluble receptor (ng/mL) | 21.7 ± 5.7 | 20.7 ± 5.3 | 22.0 ± 5.4 | 21.0 ± 5.8 | 20.5 ± 5.3 | 22.2 ± 6.1 | 21.1 ± 5.3 | 21.6 ± 5.9 | 20.9 ± 5.7 | 21.4 ± 5.1 |
Data are mean ± SD or percentage (%).
*
A number of 70–97 participants with missing values for total fat mass and total lean mass.