Table 3.
Changes in resting metabolic rate according to baseline tertiles of thyroid hormone
| Tertiles of Thyroid Hormone
|
P trend | |||
|---|---|---|---|---|
| T1 | T2 | T3 | ||
| Resting metabolic rate change, kcal/day (0–6months) | ||||
|
| ||||
| Free T3 (n=503) | ||||
| Model 1* | 0.23±21.3 | −13.7±21.6 | −45.4±21.2 | 0.003 |
| Model 2† | −14.7±21.4 | −20.2±21.4 | −47.7±21.4 | 0.04 |
| Total T3 (n=491) | ||||
| Model 1* | −21.7±21.6 | −4.20±21.4 | −52.3±21.2 | 0.02 |
| Model 2† | −29.7±21.9 | −7.72±21.1 | −45.5±21.5 | 0.26 |
| Free T4 (n=523) | ||||
| Model 1* | 6.33±21.3 | −18.9±20.3 | −48.9±21.0 | <0.001 |
| Model 2† | −3.95±21.9 | −26.4±20.8 | −51.37±21.5 | 0.001 |
| Total T4 (n=489) | ||||
| Model 1* | −13.5±21.2 | −13.7±21.1 | −52.6±21.1 | 0.01 |
| Model 2† | −15.8±21.7 | −15.1±21.2 | −52.6±21.6 | 0.03 |
| TSH (n=520) | ||||
| Model 1* | −29.8±21.3 | −11.1±21.3 | −21.8±21.2 | 0.80 |
| Model 2† | −33.5±21.3 | −18.9±21.2 | −28.0±21.2 | 0.90 |
|
| ||||
| Resting metabolic rate change, kcal/day (6–24 months) | ||||
|
| ||||
| Free T3 (n=356) | ||||
| Model 1* | 24.8±37.9 | 11.3±36.6 | 12.3±36.2 | 0.66 |
| Model 2† | 29.1±38.4 | 4.1±36.7 | 4.5±36.7 | 0.42 |
| Total T3 (n=348) | ||||
| Model 1* | 7.16±37.2 | 5.74±37.8 | 10.8±36.6 | 0.88 |
| Model 2† | 10.8±38.1 | 10.9±37.6 | 11.1±37.1 | 0.99 |
|
| ||||
| Free T4 (n=370) | ||||
| Model 1* | 18.4±37.6 | 13.4±36.7 | 20.1±37.2 | 0.94 |
| Model 2† | 13.8±37.4 | 8.10±36.7 | 9.04±36.9 | 0.85 |
| Total T4 (n=346) | ||||
| Model 1* | −0.53±36.8 | 1.60±36.6 | 27.3±36.9 | 0.26 |
| Model 2† | −0.77±37.5 | 3.67±36.6 | 29.9±37.8 | 0.30 |
| TSH (n=368) | ||||
| Model 1* | 53.8±36.4 | −11.5±36.0 | 5.46±36.6 | 0.19 |
| Model 2† | 42.5±36.7 | −16.5±36.3 | 0.60±37.1 | 0.29 |
|
| ||||
| Resting metabolic rate change, kcal/day (0–24 months) | ||||
|
| ||||
| Free T3 (n=363) | ||||
| Model 1* | 45.9±39.2 | 5.09±38.2 | −13.6±37.9 | 0.04 |
| Model 2† | 32.6±39.7 | −9.84±38.2 | −24.2±38.6 | 0.07 |
| Total T3 (n=355) | ||||
| Model 1* | 5.24±38.5 | 15.0±39.4 | −23.8±38.3 | 0.26 |
| Model 2† | −1.83±39.6 | −15.5±39.4 | −15.3±39.1 | 0.61 |
| Free T4 (n=377) | ||||
| Model 1* | 49.7±39.0 | −0.04±38.6 | −17.4±39.0 | 0.01 |
| Model 2† | 36.4±38.4 | −13.9±38.2 | −31.4±38.5 | 0.01 |
| Total T4 (n=353) | ||||
| Model 1* | 17.6±38.3 | −11.6±38.2 | −14.4±38.6 | 0.23 |
| Model 2† | 20.7±39.3 | −10.6±38.3 | −17.4±39.8 | 0.23 |
| TSH (n=375) | ||||
| Model 1* | 24.0±39.0 | −0.34±38.3 | 5.99±39.0 | 0.65 |
| Model 2† | 10.6±38.7 | −14.8±38.0 | −4.38±39.0 | 0.77 |
Data are least square means ± SE. RMR change was defined as difference between RMR assessment at baseline and RMR assessments at follow-up examinations;
*
Model 1, adjusted for age, sex, race, education, smoking, alcohol consumption, physical activity, menopausal status, hormone replacement therapy, diet groups, and baseline resting metabolic rate.
†
Model 2, further adjusted for other thyroid functional parameters.