. Author manuscript; available in PMC: 2017 Dec 1.

Published in final edited form as: Int J Obes (Lond). 2017 Jan 31;41(6):878–886. doi: 10.1038/ijo.2017.28

Table 4.

Partial Spearman correlation coefficients among changes in thyroid hormones, body weight, and metabolic parameters

0–6 months	ΔFree T3 (0–6m) (n=528)	ΔTotal T3 (0–6m) (n=505)	ΔFree T4 (0–6m) (n=552)	ΔTotal T4 (0–6m) (n=499)	ΔTSH (0–6m) (n=547)
ΔWeight (0–6 m)	0.29^***	0.30^***	−0.05	0.06	0.05
ΔResting metabolic rate (0–6 m)	0.24^***	0.25^***	0.03	0.04	−0.04
ΔSystolic blood pressure (0–6 m)	0.14^**	0.19^***	0.04	0.07	−0.02
ΔDiastolic blood pressure (0–6 m)	0.14^**	0.20^***	0.04	0.10^*	0.01
ΔGlucose (0–6 m)	0.11^*	0.09^*	0.03	0.02	−0.01
ΔInsulin (0–6 m)	0.16^***	0.20^***	−0.05	0.02	−0.01
ΔTriglycerides (0–6 m)	0.19^***	0.23^***	−0.06	0.05	0.17^***
ΔTotal cholesterol (0–6 m)	0.03	0.03	−0.02	0.05	−0.03
ΔWhole body fat mass (0–6 m) ^†	0.28^***	0.33^***	0.01	0.17^*	0.07
ΔWhole body lean mass (0–6 m) ^†	0.21^***	0.32^***	−0.09	−0.004	0.07
ΔLeptin (0–6 m)	0.17^***	0.24^***	−0.13^**	0.03	0.09^*
ΔSoluble leptin receptor (0–6 m)	−0.08	−0.06	0.06	0.12^**	0.03

6–24 months	ΔFree T3 (0–6m) (n=448)	ΔTotal T3 (0–6m) (n=429)	ΔFree T4 (0–6m) (n=469)	ΔTotal T4 (0–6m) (n=424)	ΔTSH (0–6m) (n=465)

ΔWeight (6–24 m)	−0.03	−0.006	0.06	0.05	0.09
ΔResting metabolic rate (6–24 m)	−0.08	−0.02	−0.002	0.03	0.08
ΔSystolic blood pressure (6–24 m)	−0.05	−0.06	−0.03	−0.09	0.01
ΔDiastolic blood pressure (0–6 m)	−0.04	−0.09	−0.02	−0.13^*	−0.03
ΔGlucose (6–24 m)	0.04	0.01	0.02	0.008	−0.05
ΔInsulin (6–24 m)	0.04	0.009	0.02	0.005	−0.001
ΔTriglycerides (6–24 m)	−0.09	−0.10^*	0.04	−0.01	0.03
ΔCholesterol (6–24 m)	−0.10^*	−0.10^*	0.01	−0.05	0.07
ΔWhole body fat mass (6–24 m) ^†	−0.03	0.03	0.01	0.03	0.02
ΔWhole body lean mass (6–24 m) ^†	−0.07	−0.007	−0.06	0.004	0.09
ΔLeptin (6–24 m)	−0.07	−0.11^*	0.07	−0.05	0.11^*
ΔSoluble leptin receptor (6–24 m)	−0.003	−0.04	−0.02	−0.11^*	−0.10

6–24 months	ΔFree T3 (6−24m) (n=415)	ΔTotal T3 (6−24m) (n=388)	ΔFree T4 (6−24m) (n=425)	ΔTotal T4 (6−24m) (n=377)	ΔTSH (6−24m) (n=422)

ΔWeight (6–24 m)	0.25^***	0.26^***	−0.13^**	−0.005	0.04
ΔResting metabolic rate (6–24 m)	0.15^**	0.18^**	−0.09	0.03	−0.01
ΔSystolic blood pressure (6–24 m)	0.12^*	0.12^*	−0.02	0.01	0.004
ΔDiastolic blood pressure (0–6 m)	0.16^**	0.18^***	0.01	0.11^*	0.08
ΔGlucose (6–24 m)	0.04	0.05	−0.004	0.01	0.04
ΔInsulin (6–24 m)	0.09	0.14^**	−0.13^**	0.005	0.03
ΔTriglycerides (6–24 m)	0.14^**	0.15^**	−0.12^*	0.06	0.03
ΔCholesterol (6–24 m)	0.05	−0.04	−0.05	0.03	0.05
ΔWhole body fat mass (6–24 m) ^†	0.29^***	0.20^*	−0.05	0.09	0.02
ΔWhole body lean mass (6–24 m) ^†	0.14	0.18^*	−0.22^**	−0.08	0.02
ΔLeptin (6–24 m)	0.23^***	0.28^***	−0.09	0.07	0.04
ΔSoluble leptin receptor (6–24 m)	0.01	−0.03	0.17^***	0.13^*	0.04

0–24 months	ΔFree T3 (0–24m) (n=398)	ΔTotal T3 (0–24m) (n=369)	ΔFree T4 (0–24m) (n=420)	ΔTotal T4 (0–24m) (n=359)	ΔTSH (0–24m) (n=418)

ΔWeight (0–24 m)	0.32^***	0.41^***	−0.13^**	0.10	0.11
ΔResting metabolic rate (0–24 m)	0.16^**	0.26^***	−0.03	0.12^*	−0.02
ΔSystolic blood pressure (0–24 m)	0.17^***	0.19^***	−0.03	0.06	−0.0003
ΔDiastolic blood pressure (0–6 m)	0.17^***	0.22^***	−0.02	0.09	−0.003
ΔGlucose (0–24 m)	0.17^***	0.18^***	0.004	0.10	−0.07
ΔInsulin (0–24 m)	0.24^***	0.35^***	−0.09	0.14^**	0.03
ΔTriglycerides (0–24 m)	0.14^**	0.16^**	−0.13^**	0.07	0.15^**
ΔCholesterol (0–24 m)	0.03	−0.02	0.007	0.10	0.08
ΔWhole body fat mass (0–24 m) ^†	0.34^***	0.44^***	−0.02	0.24^***	0.08
ΔWhole body lean mass (0–24 m) ^†	0.24^***	0.36^***	−0.20^**	0.09	0.12
ΔLeptin (0–24 m)	0.20^***	0.30^***	−0.12^*	0.07	0.20^***
ΔSoluble leptin receptor (0–24 m)	−0.07	−0.15^**	0.10^*	0.06	−0.03

Values were adjusted for age, sex, race, education, smoking, alcohol consumption, physical activity, menopausal status, hormone replacement therapy, and diet groups. Δ= follow-up value –baseline value.

P<0.05;

^**

P<0.01;

^***

P<0.001;

^†

further adjusted for whole body lean mass (for whole body fat mass) or whole body fat mass (for whole body lean mass); n=293 for 6 months, and n=177 for 24 months.