Table 2. Rare variants analysis using the KBAC method in the European-ancestry cohort: tolerated and non-conserved, non-exonic and variants that in controls had a MAF >0.01.

Chr	Position start	Position stop	Gene name	Transcript name(s)	P-value (one-sided)	KBAC (one-sided)	FDR (one-sided)	Sample size used	# Markers	# Multi-marker genotypes
22	45248966	45435430	PHF21B	CCDS46727.1	0.001	0.027	0.068	972	6	6
22	45152408	45288475	ARHGAP8	CCDS33664.1	0.003	0.027	0.102	972	16	8
22	45248966	45434692	PHF21B	CCDS56234.1	0.001	0.027	0.102	972	6	6
22	45248966	45435430	PHF21B	CCDS14061.1	0.002	0.027	0.102	972	6	6
22	45152408	45288475	ARHGAP8	CCDS14060.2	0.003	0.027	0.123	972	16	8

Abbreviations: Chr, chromosome; FDR, false discovery rate; KBAC, kernel-based adaptive cluster; MAF, minor allele frequency.