Fig. 1.

Effects of adenosine, inosine, guanosine and xanthine on uric acid production in AML12 cells. AML12 cells were treated with various concentrations of adenosine (a), inosine (b), guanosine (c) and xanthine (d) for 2 h in balanced salt solution (BSS). Uric acid levels in the BSS (white bars) and the cells (gray bars) were measured by the uricase method. Each value represents mean ± SEM for six wells (duplicate measurements per well). Values not sharing a common letter are significantly different at P < 0.05 among the BSS groups (Tukey test). *Significantly different at P < 0.05 from UA levels in the BSS at the same UA precursor concentrations (paired Student t test)