Fig. 3.

Effect of ENL on FBG levels (a) and HOMA-IR (b) in Type 2 diabetic model db/db mice. a Fasting blood glucose level. During 6 weeks of ENL feeding, fasting blood glucose levels were measured once a week, after mice were fasted for 3 h before blood collection. b HOMA-IR calculated from concentrations of serum glucose and insulin after 6 weeks of feeding. Each value represents the mean ± SEM for six mice. Values not sharing a common letter are significantly different at p < 0.05 by Tukey–Kramer multiple comparisons test. NOR normal m/m mice group, CNT control diabetic db/db mice group, ENL-L enterolactone-low dose (0.001 % in diet) group, ENL-H enterolactone-high dose (0.01 % in diet) group, ENL enterolactone, FBG fasting blood glucose, HOMA-IR homeostasis model assessment of insulin resistance