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. 2017 Jun 7;8:663. doi: 10.3389/fimmu.2017.00663

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Copyright © 2017 Geng, Zhong, Zhou, Zhao, Xie, Pei, Liu, Zhang, Shi and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antigen-specific regulatory T cells (asTregs) control the traffic of inflammatory effector T cells (Teffs) in hilar lymph node (hLN). (A) Similar to Figure 6A. 3 days after the i.t. transfer (day 10), chemokine receptors and adhesion molecules were analyzed on KJ1-26⁺ cells in hLN. Both antigen-matched (Co-OVA, red) and mismatched (Co-DERP1, blue) treatments were analyzed. (B) Enrichment of the CXCR3⁺, VLA-4⁺, S1p1⁻ population in DO11.10 T cells in hLN. n = 6. (C) Experimental scheme for lentivirus knockdown assay. CXCR3 and VLA-4 knockdown, and S1p1-overexpression were performed on donor inflammatory DO11.10 T cells, and they were i.t. transferred into asthmatic asTreg-recipient mice on day 7. (D) On day 10, KJ1-26⁺ cells recruited back to hLN were analyzed. n = 6. Data shown represent two independent experiments.