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. 2017 Jun 7;11:40. doi: 10.3389/fncir.2017.00040

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Copyright © 2017 Lee, Huh, Lee, Ghim, Lee and Jung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavioral performance. (A) The modified T-maze used for rats. The rats were allowed to choose freely between two targets (blue circles) that delivered water in a probabilistic manner. Breaking a photobeam sensor in front of a reward site (the two red dashed lines on top) triggered an auditory tone (CS, 1 s) that signaled a trial outcome. Water reward was delivered at the CS offset in rewarded trials. Calibration, 10 cm. (B) Rat's choice behavior during one example session. The probability of choosing the left target (P_L) is plotted in moving average of 10 trials (gray curve). The black curve represents choice probability predicted by an RL model. Tick marks denote trial-by-trial choices of the rat (upper, left choice; lower, right choice; long, rewarded trial; short, unrewarded trial). Each session consisted of four blocks of trials with different combinations of reward probabilities. Vertical lines denote block transitions and numbers on top indicate reward probabilities used in this example session. (C–E) Comparison of choice behavior during CA1 and CA3 recording sessions. (C) The relationship between log choice ratio (ordinate) and log reinforcement ratio (abscissa) is shown separately for CA1 and CA3 recording sessions. Each data point was obtained by analyzing steady-state behavioral data (trials after the proportion of higher-reward-probability target choices reaching >90% of the maximum value in each block in 7-trial moving average) during one block of trials. (D) Effects of past rewards on the rat's choice are shown separately for CA1 and CA3 recording sessions. The influence of past rewards on the rat's choice was estimated using a logistic regression model. Shown are regression coefficients averaged across four rats (mean ± SEM). Positive coefficients indicate the animal's tendency to make the same choice that was rewarded in recent trials. (E) The proportion of higher-reward-probability target choices [P(H)] in each block, the proportion of win-stay (repeating the rewarded choice) in each session, the proportion of lose-switch (switching from unrewarded choice) in each session, and choice bias (the proportion of choosing one target over the other in each session) were compared between CA1 and CA3 recording sessions. No significant difference was found in any of these measures (t-test, p > 0.1).