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. 2017 Jun 5;24(6):e00553-16. doi: 10.1128/CVI.00553-16

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Copyright © 2017 van der Most et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — A(H1N1)pdm09-specific CD4⁺ T-cell responses stratified by the participants' history of seasonal influenza vaccination and age. The graphs shown represent antigen-specific CD4⁺ T-cell responses induced by the AS03-adjuvanted or nonadjuvanted A(H1N1)pdm09 (H1N1) vaccine measured after stimulation with H1N1 split antigen (A and B) or the H1 pool of peptides (C). Data are stratified by the participants' history of seasonal influenza vaccination (Flu/No flu; panels A to C) and by age (panel B; study A only) and reported as percentages of A(H1N1)pdm09-specific CD4⁺ T cells expressing at least two immune markers (IFN-γ, IL-2, TNF-α, or CD40L). Data for time zero (D0), day 21 (D21), and day 42 (D42) in study A supplement previously published data for the cohorts without stratification for seasonal influenza vaccination history (6). y, years. M, month. Q1 and Q3, first and third quartiles. Min and Max, minimum and maximum values.

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