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. 2005 Jan 7;33(1):114–125. doi: 10.1093/nar/gki155

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© 2005, the authors Nucleic Acids Research, Vol. 33 No. 1 © Oxford University Press 2005; all rights reserved

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact journals.permissions@oupjournals.org.

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ASO and siRNA differently influence target mRNA stability and translation. (A) Schematic diagram of DHBV sgRNA. The initiation codons, hybridization sites for antisense oligos and labeled probes are depicted. The drawing is not to scale. (B) Northern-blot analysis with probes discriminating the putative mRNA cleavage fragments upon cotransfection of hepatoma cells with a construct encoding sgRNA and different antisense compounds. Equal amounts of RNA were loaded. (C) Immunoblotting of the concomitantly expressed preS/S proteins, different isoforms are indicated. Equal amounts of protein were loaded.