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. 2005 Jan 7;33(1):143–151. doi: 10.1093/nar/gki156

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© 2005, the authors Nucleic Acids Research, Vol. 33 No. 1 © Oxford University Press 2005; all rights reserved

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Scheme 1 — Schematic representations of DNA duplexes formed by oligonucleotides that contain nicks and/or gaps at regular intervals. (A) The pairing of the 42mer oligonucleotides N1 and N2 to produce a nicked-DNA duplex with nicks in the backbone at every 21 bp. (B) The formation of gapped-DNA, with 2 nt gaps at every 21 bp, by the pairing of the 44mer oligonucleotides G1 and G2. (C) The formation of nicked-gapped-DNA, with alternating nicks and 2 nt gaps at every 21 bp, by the pairing of the 42mer oligonucleotide N1 and the 44mer oligonucleotide G2. Oligonucleotide sequences are given in Materials and Methods.