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. 2005 Jan 7;33(1):152–161. doi: 10.1093/nar/gki157

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© 2005, the authors Nucleic Acids Research, Vol. 33 No. 1 © Oxford University Press 2005; all rights reserved

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Effect of strand bias and sequence specificity in the absence of SA. The 45mer substrates containing either 15 homopolymeric 3′-dA on both sides of a 15 base sequence of mixed base composition (3′-A/3′-A) or 3′-dT on both ends (3′-T/3′-T) were constructed by annealing T-5B-mixed with c-mixed-15(T) or A-5B-mixed with c-mixed-15(A). Full duplex substrates were generated by polymerase extension and each duplex was assayed for DNA-PK activation at concentrations of 100 or 500 fmol of DNA as described in Figure 2, except SA was not included.