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. 2005 Jan 12;33(1):201–212. doi: 10.1093/nar/gki158

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© 2005, the authors Nucleic Acids Research, Vol. 33 No. 1 © Oxford University Press 2005; all rights reserved

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Multiple cleavage sites in a poly(A) site. (A) Histogram of the genomic distance between adjacent cleavage sites in genes. (B) Histogram of the distance between the 5′-most cleavage site and other downstream cleavage sites when multiple cleavage sites are present in a poly(A) site (mean = 7.9 nt, median = 5 nt). (C) The relationship between the number of PAS hexamers (AAUAAA and other 11 variants) associated with a poly(A) site and the number of cleavage sites in the poly(A) site. Error bars are standard error of the mean (SEM). (D) Correlation between the number of cleavage sites and the number of supporting cDNA/EST sequences for poly(A) sites (Pearson correlation coefficient R = 0.83). (E) Histogram of the distance between a poly(A) site and the associated PAS when only one PAS is present. Only human poly(A) sites are used in (A–E).