Table1.

Included trials

	TRUST3	ECOST5	IN-TIME12
No. of centres	102 USA sites	43 French sites	26 German sites, 10 sites elsewherea
Patient eligibility	Class1 indication for ICD, not pacemaker dependent	Indication for ICD, not NYHA class IV	Indication for ICD or CRT-D, heart failure (≥ 3 months), NYHA class II or III, LVEF ≤ 35%
Primary objective	To evaluate safety and efficacy of extended IO intervals	To compare major CVAEs including all-cause death	To compare heart failure outcomes using composite (“Packer”) scoreb
Follow-up schedule
HM group	IO at 3M and 15M. HM replaced IO at 6M, 9M, and 12M	IO at 1-3M, 15M, and 27M. HM replaced IO at 9M and 21M	IO at 12M, and in-between according to hospital routine
Control group	IO every 3M	IO at 1-3M, then every 6M	Same as in the HM group
Blinded endpoint committee	No	Yes	Yes

^aDenmark (three sites), Czech Republic (two), Israel (two), Australia (one), Austria (one), Latvia (one).

^bThe score combines all-cause death, overnight hospitalization for heart failure, change in NYHA class, and change in patient global self-assessment.

CRT-D, cardiac resynchronization therapy defibrillator; CVAE, cardiovascular adverse event; ECOST, Effectiveness and cost of ICDs follow-up schedule with telecardiology; HM, Home Monitoring; ICD, implantable cardioverter-defibrillator; IN-TIME, Influence of HM on mortality and morbidity in heart failure patients with impaired left ventricular function; IO, in-office visit; LVEF, left ventricular ejection fraction; M, months; NYHA, New York Heart Association; TRUST, Lumos-T safely reduces routine office device follow-up.