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. 2017 Jun 1;8:15692. doi: 10.1038/ncomms15692

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Schematic of granule (yellow) transport by myoVa ensembles through the actin cortex. Transport from A to B (red arrow) presents a number of physical and directional challenges. (b) Zoom in from A. Multiple-myoVa motors (black) are bound and free to diffuse (dashed arrows) on the surface of a lipid-bound cargo (yellow). One or more motors at different regions on the cargo surface (green) can simultaneously engage a single filament. In this illustration two sets of motors interact with individual actin filaments (blue, magenta) and undergo a tug-of-war to determine the direction of cargo transport. (c) STORM image of 3D actin network and intersections created by stringing actin between 3 μm beads; Z-position shown in colour. Scale bar: 2,000 nm. (d) Time sequence of liposome (yellow) transported by myoVa motors turning (red dashed arrow) at actin filament intersection. Actin Z-position is defined by the colour bar in B. Scale bar: 500 nm. (e) Liposome continuing straight through a different 3D intersection. Scale bar: 500 nm.