Fig. 7.

Predicted gene interaction networks regulated by baculovirus infection. The gene interaction networks were retrieved from the STRING protein-protein interaction database. The interaction networks were exported to Cytoscape for visualization. Gray nodes indicate their presence in the corresponding gene sets. Three types of interaction modes were included in the interaction network: the red edge indicates correlated expression; the black edge denotes predicted protein-protein interactions; and the purple edge represents known protein-protein interactions. The false discovery rate for each enriched term is indicated in the figure. A, interaction network for the genes up-regulated by baculovirus infection. The interaction network indicated that anatomical structure formation was up-regulated by baculovirus infection. B, interaction network for the genes down-regulated by immune challenge with baculovirus. Among the down-regulated genes, more interaction networks related to translation and metabolic pathways such as CM, fatty acid metabolism, energy metabolism, and purine metabolism were significantly enriched, suggesting substantial modulation of host physiological functions.