Figure 1.

Effect of enoxaparin on infarct volume in the cortex of mice with cold-induced traumatic brain injury (TBI).

(A) Damaged tissue is defined by a decrease in staining intensity and an example of border demarcation is illustrated in these consecutive images (represented as 1, 1’, 1’’ and so on) (Cresyl violet staining) (scale bars: 1mm). 1–1’’ indicates control group (TBI + isotonic saline solution), 2–2’’ indicates “3 mg/kg enoxaparin group (TBI + 3 mg/kg enoxaparin)” and 3–3’’ indicates “10 mg/kg enoxaparin group (TBI + 10 mg/kg enoxaparin)”. * indicates the infarct area. (B) Infarct volume at 24 hours after surgery. All values are given as the mean ± SEM (mm³). Seven rats were used in each group. *P < 0.05, vs. control group (Kruskal-Wallis tests followed by Mann-Whitney U tests).