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. 2017 Jun 6;15:128. doi: 10.1186/s12967-017-1230-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Analysis of TRAP staining: MRONJ (BP) vs. OM vs. ORN vs. control. a Shows 2 TRAP+ osteoclasts (arrowheads) within an OM histological section. b Depicts a TRAP+ osteoclast (arrowhead) within a control histological section. Note the direct contact with the bone surface. c Illustrates the number of TRAP+ osteoclasts per ROI. d Depicts the respective osteoclast labeling indices. * marks statistical outliers. For detailed data see Table 2. MRONJ (BP) medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy, OC osteoclasts, OM osteomyelitis, ORN osteoradionecrosis, DC-STAMP dendritic cell-specific transmembrane protein, TRAP tartrate-resistant acid phosphatase