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. 2017 Jan 31;5(1):e00294. doi: 10.1002/prp2.294

Table 1.

Inhibitory effect of resveratrol in liver microsomes and heterologously expressed isozymes (only studies that measured enzyme activity are included)

Enzyme Substrate Model IC50 (μmol/L) Ki (μmol/L) Reference
CYP3A4 Testosterone Human liver microsome 4.0 Piver et al. 2001
Rat liver microsome 20 Piver et al. 2001
Recombinant isozyme 10 Piver et al. 2001
Recombinant isozyme 15 Piver et al. 2003
Human liver microsome 25 Piver et al. 2003
Recombinant isozyme 1.1 Yu et al. 2003;
CYP3A11 (homolog) Aripiprazole Nifedipine Recombinant isozyme Mouse liver microsome 6.8
15.8
Zhan et al. 2015Wang et al. 2015
CYP1A1 EROD Human HepG2 microsome 1.0 0.42 Ciolino and Yeh 1999
Human HepG2 cell 1.0 Ciolino and Yeh 1999
Human MCF‐7 cell 0.5 Ciolino and Yeh 1999
Recombinant isozyme 1.2 Chang et al. 2001
Recombinant isozyme 40 Piver et al. 2001
Recombinant isozyme 30 Piver et al. 2003;
CYP1A2 EROD Recombinant isozyme 15.5 Chang et al. 2001
Recombinant isozyme 30 Piver et al. 2001
Human liver microsome 25 Piver et al. 2003
Phenacetin Mouse liver microsome 127.3 Wang et al. 2015
CYP1B1 EROD Recombinant isozyme 0.8 Chang et al. 2001
Recombinant isozyme 40 Piver et al. 2003
CYP2B1 EFC Rat liver microsomea Huynh and Teel 2002
CYP2B6 BROD Recombinant isozyme >50 Piver et al. 2003
Recombinant isozyme 100 Piver et al. 2003
Human liver microsome 100 Piver et al. 2003
CYP2D6 Bufuralol Human liver microsome > 50 Yu et al. 2003
Aripiprazole Recombinant isozyme 87.9 Zhan et al. 2015
CYP2E1 Chlorzoxazone Human liver microsome 150 Piver et al. 2001
Recombinant isozyme 50 Piver et al. 2003;
Human liver microsome Mouse liver microsome 74.3 50 Piver et al. 2003Wang et al. 2015
PNPH Rat liver microsome 18.5 Mikstacka et al. 2002
CYP2C9 Diclofenac Human liver microsome >50 Yu et al. 2003
CYP 2C19 DBF Human liver microsome 22.5 Orsini et al. 2016

BROD, 7‐benzoxy resorufin; EFC, 7‐ethoxy‐4‐trifluormethyl courmarin; EROD, 7‐ethoxyresorufin; DBF, O‐benzylfluorescein benzyl ester; PNPH, p‐nitrophenol hydroxylase.

a

< 0.05 for percent inhibition.