Table 1.

Inhibitory effect of resveratrol in liver microsomes and heterologously expressed isozymes (only studies that measured enzyme activity are included)

Enzyme	Substrate	Model	IC50 (μmol/L)	Ki (μmol/L)	Reference
CYP3A4	Testosterone	Human liver microsome	4.0		Piver et al. 2001
		Rat liver microsome	20		Piver et al. 2001
		Recombinant isozyme	10		Piver et al. 2001
		Recombinant isozyme	15		Piver et al. 2003
		Human liver microsome		25	Piver et al. 2003
		Recombinant isozyme	1.1		Yu et al. 2003;
CYP3A11 (homolog)	Aripiprazole Nifedipine	Recombinant isozyme Mouse liver microsome	6.8 15.8		Zhan et al. 2015Wang et al. 2015
CYP1A1	EROD	Human HepG2 microsome	1.0	0.42	Ciolino and Yeh 1999
		Human HepG2 cell	1.0		Ciolino and Yeh 1999
		Human MCF‐7 cell	0.5		Ciolino and Yeh 1999
		Recombinant isozyme		1.2	Chang et al. 2001
		Recombinant isozyme	40		Piver et al. 2001
		Recombinant isozyme	30		Piver et al. 2003;
CYP1A2	EROD	Recombinant isozyme		15.5	Chang et al. 2001
		Recombinant isozyme	30		Piver et al. 2001
		Human liver microsome		25	Piver et al. 2003
	Phenacetin	Mouse liver microsome	127.3		Wang et al. 2015
CYP1B1	EROD	Recombinant isozyme		0.8	Chang et al. 2001
		Recombinant isozyme	40		Piver et al. 2003
CYP2B1	EFC	Rat liver microsomea			Huynh and Teel 2002
CYP2B6	BROD	Recombinant isozyme	>50		Piver et al. 2003
		Recombinant isozyme	100		Piver et al. 2003
		Human liver microsome		100	Piver et al. 2003
CYP2D6	Bufuralol	Human liver microsome	> 50		Yu et al. 2003
	Aripiprazole	Recombinant isozyme	87.9		Zhan et al. 2015
CYP2E1	Chlorzoxazone	Human liver microsome	150		Piver et al. 2001
		Recombinant isozyme	50		Piver et al. 2003;
		Human liver microsome Mouse liver microsome	74.3	50	Piver et al. 2003Wang et al. 2015
	PNPH	Rat liver microsome	18.5		Mikstacka et al. 2002
CYP2C9	Diclofenac	Human liver microsome	>50		Yu et al. 2003
CYP 2C19	DBF	Human liver microsome	22.5		Orsini et al. 2016

BROD, 7‐benzoxy resorufin; EFC, 7‐ethoxy‐4‐trifluormethyl courmarin; EROD, 7‐ethoxyresorufin; DBF, O‐benzylfluorescein benzyl ester; PNPH, p‐nitrophenol hydroxylase.

^a P < 0.05 for percent inhibition.