Table 1.
Comparison of multifunctional genes from FCM gene-sets and KEGG pathways. Multifunctional genes that were involved in at least 3 FCM DC gene-sets were also overlapping between KEGG pathways
| Multifunctional genes | No. of pathways | No. of FCM DC clusters | Enriched pathway names | FCM cluster |
|---|---|---|---|---|
| NFATC4 | 5 | 5 | MAPK_SIGNALING, VEGF_SIGNALING, NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY, T_CELL_RECEPTOR_SIGNALING, B_CELL_RECEPTOR_SIGNALING | 34,35,37,43,45 |
| CCL23 | 2 | 4 | CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, CHEMOKINE_SIGNALING_PATHWAY | 17,18,39,40 |
| GAB2 | 2 | 4 | FC_EPSILON_RI_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 13,16,19,31 |
| IL21R | 2 | 4 | CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, JAK_STAT_SIGNALING | 7,8,20,24 |
| VASP | 2 | 4 | FOCAL_ADHESION, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 1,4,10,50 |
| ANAPC1 | 2 | 3 | CELL_CYCLE, UBIQUITIN_MEDIATED_PROTEOLYSIS | 7,8,29 |
| ASAP1 | 2 | 3 | ENDOCYTOSIS, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 30,31,39 |
| CCND2 | 3 | 3 | CELL_CYCLE, FOCAL_ADHESION, JAK_STAT_SIGNALING | 7,14,29 |
| CD80 | 4 | 3 | CELL_ADHESION_MOLECULES_CAMS, TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY, INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION, ISGs | 36,45,46 |
| CDC16 | 2 | 3 | CELL_CYCLE, UBIQUITIN_MEDIATED_PROTEOLYSIS | 8,14,29 |
| CDK4 | 2 | 3 | CELL_CYCLE, T_CELL_RECEPTOR_SIGNALING | 23,33,44 |
| DNM2 | 2 | 3 | ENDOCYTOSIS, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 3,12,31 |
| EP300 | 3 | 3 | JAK_STAT_SIGNALING, CELL_CYCLE, TGF_BETA_SIGNALING, | 3,4,50 |
| HSPB1 | 2 | 3 | MAPK_SIGNALING, VEGF_SIGNALING | 5,25,50 |
| IL1R2 | 3 | 3 | MAPK_SIGNALING, CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, HEMATOPOIETIC_CELL_LINEAGE | 6,21,22 |
| ITGAV | 2 | 3 | FOCAL_ADHESION, CELL_ADHESION_MOLECULES_CAMS | 2,25,50 |
| MAP3K1 | 3 | 3 | MAPK_SIGNALING_PATHWAY, UBIQUITIN_MEDIATED_PROTEOLYSIS, RIG_I_LIKE_RECEPTOR_SIGNALING | 1,27,50 |
| POLR1C | 2 | 3 | RNA_POLYMERASE, CYTOSOLIC_DNA_SENSING | 3,31,33 |
| PPP3CB | 6 | 3 | MAPK_SIGNALING, APOPTOSIS, VEGF_SIGNALING, NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY, T_CELL_RECEPTOR_SIGNALING, B_CELL_RECEPTOR_SIGNALING | 16,28,29 |
| RPS6KB1 | 4 | 3 | ERBB_SIGNALING, MTOR_SIGNALING, TGF_BETA_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 16,23,28 |
| TNFRSF1A | 3 | 3 | MAPK_SIGNALING, CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, APOPTOSIS | 5,25,50 |
| WAS | 2 | 3 | CHEMOKINE_SIGNALING, FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 23,28,44 |
| PIK3R1 | 14 | 3 | T CELL RECEPTOR SIGNALING, B CELL RECEPTOR SIGNALING, TOLL LIKE RECEPTOR SIGNALING and 11 others | 7,8,24 |