Fig. 1.

Change in tumour volumes following treatment with DXR HCl liposome injections or placebo. The figure shows: a change in tumour volumes in syngeneic fibrosarcoma-bearing mice treated with the SPIL DXR HCl liposome injection (n = 11), reference DXR HCl liposome injection (n = 15) or placebo (n = 15). One animal in the reference DXR HCl liposome group was found dead on Day 28. b Change in tumour volumes in MX-1-bearing mice treated with either the SPIL DXR HCl liposome injection, reference DXR HCl liposome injection or placebo (n = 10 per group). Two animals in the 6 mg/kg SPIL DXR HCl liposome injection group were found dead: one on Day 28 and one on Day 35. Two animals in the reference DXR HCl liposome group were found dead: one on Day 28 and one on Day 38. In both studies, differences were analysed by two-way analysis of variance followed by Bonferroni post tests. P values <0.05 were considered significant. Error bars indicate the standard error of mean for replicate animals. Abbreviations: DXR, doxorubicin; HCl, hydrochloride; ns, non-significant; SEM, standard error of mean; SPIL, Sun Pharmaceutical Industries Ltd.