Table 6.
Cox regression analysis (univariate) assessment of biomarkers for prediction of allograft loss due to CPR versus other causes
| Serum Biomarker | RR (95% CI) | P Value | β/SEM |
|---|---|---|---|
| Univariate | |||
| IgA, mg/ml | NS (0.12) | ||
| Norm Gd-IgA1, % | NS | ||
| Total Gd-IgA1,U/ml | NS | ||
| IgG, mg/ml | NS | ||
| Norm IgG-autoAb, OD | NS | ||
| Total IgG-autoAb, U/ml | NS | ||
| Norm IgA-autoAb, OD | 2.34 (0.94 to 5.84) | NS (0.07) | +1.82 |
| Total IgA-autoAb, U/ml | 1.41 (1.10 to 1.81) | <0.01 | +2.67 |
Thirty-four recipients lost their allograft: 17 due to CPR and 17 due to other causes. β/SEM indicates the weight of the covariate with increasing (+) and decreasing (−) the risk. Gd-IgA1 is the major autoantigen. Norm, normalized.