Table 2.
Histology, DSA, and renal function at the time of ABMR-proven biopsy
| Parameters | Preexisting Anti-HLA DSA ABMR (n=103) | De Novo Anti-HLA DSA ABMR (n=102) | P Value |
|---|---|---|---|
| Histology | |||
| g (0–3), mean (SD) | 1.71 (1.02) | 1.06 (0.91) | <0.001 |
| ptc (0–3), mean (SD) | 1.76 (0.98) | 1.66 (1.00) | 0.47 |
| C4d positive, n (%) | 53 (51.46) | 39 (42.39) | 0.13 |
| cg (0–3), mean (SD) | 0.48 (0.94) | 1.28 (1.15) | <0.001 |
| i (0–3), mean (SD) | 0.61 (0.92) | 1.23 (1.01) | <0.001 |
| t (0–3), mean (SD) | 0.59 (0.90) | 1.01 (1.11) | 0.003 |
| v (0–3), mean (SD) | 0.32 (0.65) | 0.22 (0.60) | 0.29 |
| ci (0–3), mean (SD) | 0.96 (1.04) | 1.60 (0.92) | <0.001 |
| ct (0–3), mean (SD) | 0.99 (0.99) | 1.60 (0.91) | <0.001 |
| cv (0–3), mean (SD) | 1.26 (1.00) | 1.44 (0.98) | 0.2 |
| ah (0–3), mean (SD) | 0.97 (0.92) | 1.53 (1.05) | <0.001 |
| Immunology at the time of the ABMR biopsy | |||
| Anti-HLA DSA class 1, n (%) | 40 (38.83) | 26 (25.49) | |
| Anti-HLA DSA class 2, n (%) | 63 (61.17) | 76 (74.51) | 0.02 |
| Anti-HLA DSA MFI, median [IQR] | 2561 [1252–6937] | 7295 [1948–11,814] | <0.001 |
| Renal function | |||
| eGFR, ml/min per 1.73 m2, mean (SD) | 39.00±18.26 | 41.65±21.19 | 0.34 |
| Proteinuria, g/g creatinine, mean (SD) | 0.51±1.05 | 1.51±2.51 | <0.001 |
g, glomerulitis; ptc, peritubular capillaritis; cg, transplant glomerulopathy; i, interstitial inflammation; t, tubulitis; v, endarteritis; ci, interstitial fibrosis; ct, tubular atrophy; cv, arteriosclerosis; ah, arteriolar hyaline thickening; MFI, mean fluorescence intensity.