Table 4.
Factors associated with kidney allograft loss in the multivariate analysis
| Factors | No. of patients | No. of events | HR | 95% CI | P Value | Internal Validation HR 95% CI Bootstrap BCA | |
|---|---|---|---|---|---|---|---|
| GFR, ml/min per 1.73 m2 | ≥60 | 29 | 8 | 1 | — | — | |
| 30–60 | 105 | 37 | 1.30 | (0.60 to 2.82) | |||
| <30 | 60 | 32 | 3.27 | (1.48 to 7.23) | <0.001 | (1.31 to 3.21) | |
| Proteinuria, g/g creatinine | <0.30 | 96 | 22 | 1 | — | — | |
| ≥0.30 | 98 | 55 | 2.44 | (1.47 to 4.09) | <0.001 | (1.53 to 4.31) | |
| DSA characteristic | Preexisting DSA | 101 | 28 | 1 | — | — | |
| De novo DSA | 93 | 49 | 1.82 | (1.07 to 3.08) | 0.03 | (1.01 to 3.28) | |
| Transplant glomerulopathy | Low score: 0 | 109 | 29 | 1 | — | — | |
| (cg) score | High score ≥1 | 85 | 48 | 2.25 | (1.34 to 3.79) | 0.002 | (1.19 to 3.81) |
The final multivariate Cox model was obtained by entering the risk factors from the univariate model that achieved P≤0.10 as the thresholds in a single multivariate proportional hazards model. The final multivariate model was adjusted for the following parameters: recipient’s sex, donor’s sex, DD, GFR, proteinuria, DSA characteristics, interstitial fibrosis and tubular atrophy, C4d deposition, transplant glomerulopathy, hyalinosis, solumedrol, and plasmapheresis. BCA, Bias-corrected and accelerated bootstrap; —, no 95% CI.