Table 3.
Association of klotho with rapid kidney function decline (>3 ml/min per yr)
| Exposure | N | ≥3 ml/min per yr | Model 1 | Model 2 | Model 3 | Model 4 |
|---|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||
| Klotho, per doubling | 2496 | 702 | 0.92 (0.80 to 1.07) | 0.87 (0.75 to 1.01) | 0.84 (0.72 to 0.97) | 0.85 (0.73 to 0.98) |
| Klotho quartiles | ||||||
| <479 | 610 | 180 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 459–630 | 632 | 177 | 0.93 (0.72 to 1.19) | 0.94 (0.73 to 1.21) | 0.91 (0.70 to 1.18) | 0.92 (0.71 to 1.19) |
| 631–816 | 632 | 168 | 0.87 (0.68 to 1.12) | 0.86 (0.67 to 1.11) | 0.82 (0.63 to 1.06) | 0.83 (0.64 to 1.08) |
| >816 | 622 | 177 | 0.93 (0.72 to 1.19) | 0.83 (0.64 to 1.07) | 0.77 (0.59 to 1.01) | 0.79 (0.61 to 1.03) |
Model 1 = unadjusted analysis. Model 2 = adjusted for age, sex, race, study site, and baseline eGFR. Model 3 = Model 2+diabetes, cardiovascular disease, hypertension, and urine albumin-to-creatinine ratio. Model 4 = Model 3+calcium, phosphorus, parathyroid hormone, and FGF-23. Interactions: klotho × FGF-23, P=0.7; klotho × eGFR, P=0.3; klotho × phosphorus, P=0.9. OR, odds ratio; 95% CI, 95% confidence interval; ref, reference.