Table 4.
Association of klotho with incident CKD (eGFR<60 ml/min per 1.73 m2 and >1 ml/min per yr decline)
| Exposure | N | Incident CKD | Rate, %/yr | Model 1 | Model 2 | Model 3 | Model 4 |
|---|---|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | ||||
| Klotho, per doubling | 1914 | 536 | 4.81 | 0.90 (0.79 to 1.02) | 0.89 (0.77 to 1.01) | 0.89 (0.77 to 1.02) | 0.90 (0.78 to 1.04) |
| Klotho quartiles | |||||||
| <479 | 438 | 134 | 5.11 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 459–630 | 474 | 136 | 5.05 | 0.99 (0.79 to 1.23) | 0.86 (0.69 to 1.07) | 0.83 (0.66 to 1.03) | 0.84 (0.67 to 1.05) |
| 631–816 | 485 | 130 | 4.46 | 0.87 (0.70 to 1.09) | 0.84 (0.66 to 1.01) | 0.81 (0.65 to 1.01) | 0.84 (0.67 to 1.04) |
| >816 | 517 | 136 | 4.68 | 0.92 (0.73 to 1.14) | 0.92 (0.73 to 1.14) | 0.91 (0.73 to 1.14) | 0.93 (0.74 to 1.17) |
Excludes those with eGFR<60 ml/min per 1.73 m2 at baseline. Model 1 = unadjusted analysis. Model 2 = adjusted for age, sex, race, study site, and baseline eGFR. Model 3 = Model 2+diabetes, cardiovascular disease, hypertension, and urine albumin-to-creatinine ratio. Model 4 = Model 3+calcium, phosphorus, parathyroid hormone, and FGF-23. Interactions: klotho × FGF-23, P=0.8; klotho × eGFR, P=0.7; klotho × phosphorus, P=0.2. OR, odds ratio; 95% CI, 95% confidence interval; ref, reference.