Table 5.
Nominal multivariate analysis of parameters associated with eGFR levels
| Parameters | Adjusted OR (95% CI) | P Value |
|---|---|---|
| Age, per increase of 1 yr | 1 (0.96 to 1.11) | 0.28 |
| Hypertension, yes versus no | 1 (0.19 to 5.04) | 0.99 |
| Symptomatic carrier versus asymptomatic carrier | 18.8 (2.96 to 200) | 0.001 |
| eGFR-1, per increase of 1 ml/min per 1.73 m2 | 0.9 (0.85 to 0.96) | <0.001 |
| Urine protein-to-creatinine ratio, per increase of 1 g/mmol | 2 (0.78 to 5.74) | 0.14 |
| Urine PBG-to-creatinine ratio, per increase of 1 μmol/mmol creatinine | 0.9 (0.87 to 1.1) | 0.67 |
| PEPT2 genotype | ||
| *1/*1 versus *1/*2 | 4.7 (0.8 to 35.4) | 0.08 |
| *1/*1 versus *2/*2 | 18.5 (2.38 to 232) | 0.004 |
| *1/*1 versus *2 | 6.8 (1.34 to 46.2) | 0.01 |
Adjusted ORs were calculated using a multivariate model incorporating all covariates listed in Table 4, which were associated (P<0.1) with an eGFR<60 ml/min per 1.73 m2 in the univariate analysis.