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KS-Kcnj10−/− adult mice show impaired response to HCTZ and furosemide. (A) Urine sodium and (B) potassium excretion before and after a single dose of HCTZ. (C) Urine sodium and (D) potassium excretion before and after a single dose of furosemide. (E) Urine sodium and (F) urine potassium after a single dose of amiloride (n=8–9). *P<0.05, **P<0.01, ****P<0.001 analyzed by two-way ANOVA.
