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. Author manuscript; available in PMC: 2017 Nov 8.
Published in final edited form as: Biochemistry. 2016 Oct 26;55(44):6150–6161. doi: 10.1021/acs.biochem.6b00453

Figure 5. QLS reveals that dimers form lower molecular weight aggregates than monomer.

Figure 5

QLS was used as a non-invasive method to determine the population distribution of detectable aggregates for each peptide. At t = 0, t = ¼ max, t = ½ max, t = max triplicate sample recordings were made using 10× 10 sec acquisitions in a DynaPro® plate reader. The average hydrodynamic radii (RH) for species detected in (A) buffer and preparations of (B) Aβ(M1-42), (C) [Aβ(M1-42)]DiY and (D) [Aβ(M1-42)]Q-K are expressed as percentage intensity detected and labelled with the average RH is indicated. ND means no signals were detected.