Table 2.
Single-Center Outcomes of Donations After Circulatory Death Versus Donations After Brain Death
| Study | Year | DCD or DBD (No. of Patients) | % Patient Survival at 1, 3, and 5 years | % Graft Survival at 1, 3, and 5 years | Donor Age, y | Recipient Age, y | Mean WIT, min | Mean CIT, min | Mean MELD |
|---|---|---|---|---|---|---|---|---|---|
| D’Alessandro et al.69 | 2000 | DCD (19) | -, 72.6, - | -, 53.8, - | 32.0 ± 15.1 | 47.4 ± 18.5 | 16.4 ± 10.9 | 474 ± 138 | |
| DBD (364) | -, 84.8, - | -, 80.9, - | 32.8 ± 15.9 | 47.7 ± 14.3 | 504 ± 150 | ||||
| Abt et al.70 | 2003 | DCD (n=15) | 79.0, 79.0, - | 71.8, 71.8, - | 30.1 ± 10.4 | 20.4 ± 6 | 366.4 ± 131 | ||
| DBD (n=221) | 90.9, 77.7, - | 85.4, 73.9, - | 38.4 ± 17.4 | 464.0 ± 149 | |||||
| Manzarbeitia et al.71 | 2004 | DCD (n=19) | 89.5, 83.5 (2 year), - | 33.95 ± 17.93 | 19.67 ± 7.68 | 574 ± 84 | |||
| DBD (n=311) | 84.2, 82.0 (2 year), - | ||||||||
| Muiesan et al.72 | 2005 | DCD (n=32) | 89.6, -, - | 86.5, -, - | 36 ± 14.9 | 38.4 (0.7–72) | 14 ± 5.3 | 516 (312–858) | |
| DBD (n=0) | |||||||||
| Fujita et al.28 | 2007 | DCD (n=24) | 86.8, 81.7, - | 69.1, 58.6, - | 31.6 | 51.1 | 12.8 ± 7.4 | 482 | 22.1 |
| DBD (n=1209) | 84.0, 76.0, - | 78.7, 70.2, - | 35.1 | 42 | 497 | 23.6 | |||
| Detry et al.31 | 2009 | DCD (n=13) | 100, 78.5 (2yr), - | 100, 78.5 (2 y), - | 51 (25–71) | 55 (50–70) | <30 | 295 | 14.2 (8–25) |
| DBD (n=0) | |||||||||
| Grewal et al.27 | 2009 | DCD (n=108) | 91.5, 88.1, 88.1 | 79.3, 74.5, 71.0 | 41 ± 17 | 55 ± 11 | 22.3 | 378 ± 102 | 17 ± 7.9 |
| DBD (n=1328) | 87.3, 81.1, 77.2 | 81.6. 74.7. 69.1 | 48 ± 20 | 55 ± 10 | 429 ± 126 | 18 ± 8.6 | |||
| Pine et al.73 | 2009 | DCD (n=39) | 82.1, 100, - | 79.5, 63.6, - | 41.85 (12–68) | 50.59 (18–67) | 352.21 (161–606) | 14.23 (6–26) | |
| DBD (n=39) | 68.2, 100, - | 97.4, 97.4, - | 42.87 (19–69) | 49.38 (22–66) | 593.87 (130–956) | 15.23 (6–32) | |||
| Skaro et al.21 | 2009 | DCD (n=32) | 74.0, 74.0,- | 61.3, 52.6, - | 43.1 ± 17.6 | 53.1 ± 12.8 | 15.1 ± 4.6 | 330 ± 90 | 22.9 ± 10.2 |
| DBD (n=237) | 90.4, 80.7, - | 85.2, 74.2, - | 44.7 ± 17.6 | 54.9 ± 10.0 | 312 ± 90 | 21.9 ± 10.1 | |||
| de Vera et al.22 | 2009 | DCD (n=141) | 79, -, 70, 57 (10yr) | 69, - 56, 44 (10y) | 37.1 ± 15.9 | 53.1 ± 10.7 | 19.8 ± 8.8 | 657 ± 170 | 18.3 ± 9 |
| DBD (n=282) | 85, -, 76, 64 (10yr) | 82, -, 73, 63 (10 y) | 39.1 ± 16.1 | 53.7 ± 9.3 | 636 ± 177 | 18.5 ± 9 | |||
| Bartlett et al.30 *pediatric | 2010 | DCD (n=14) | 100, -, - | 100, -, - | 23 ± 10.64 | 7 (8 mo-16 y) | 16 (11–29) | 420 (330–504) | - |
| DBD (n=0) | |||||||||
| Foley et al.32 | 2011 | DCD (n=87) | 84, -, 68, 54 (10yr) | 69, -, 56, 43 (10 y) | 35.8 ± 13.3 | 50.5 ± 13.1 | 20.8 ± 9.4 | 432 ± 138 | 19.7 ± 8.9 |
| DBD (n=1157) | 91, -, 81, 67 (10yr) | 86, -, 76, 60 (10 y) | 36.5 ± 13.3 | 47.5 ± 16.7 | 498 ± 138 | 20.1 ± 8.7 | |||
| Hong et al.43 | 2011 | DCD (n=81) | 78, 62, 53 | 36 ± 10 | 54 ± 11 | 26 ± 9 | 375 ± 138 | 24 ± 10 | |
| DBD (n=0) | |||||||||
| Croome et al.26 | 2012 | DCD (n=36) | 91, 80 (2yr) | 91, 73 (2 y) | 41.8 ±13.19 | 53.6 ± 8 | 35 ± 18 | 336 ± 66 | 17.5 ± 8.3 |
| DBD (n=327) | 45.93 ± 10.04 | 54.95 ± 10.07 | 432 ± 150 | 18.98 ± 9.79 | |||||
| Leithead et al.23 | 2012 | DCD (n=88) | 84.9, 78.0, - | 83.7, 77.0, - | 46.4 ± 16.1 | 55.7 ± 8.5 | 20.1 ± 9.0 | 448 ± 114 | 14 ± 5 |
| DBD (n=88) | 90.5, 83.4, - | 88.2, 81.3, - | 50.4 ± 14.6 | 56.0 ± 9.2 | 498 ± 144 | 13 ± 4 | |||
| Meurisse et al.25 | 2012 | DCD (n=30) | 93, 85, 85 | 90, 82, 82 | 51 (37–59) | 60 (52–65) | 24 (18–30) | 414 (325–471) | 15 (11–17) |
| DBD (n=385) | 88, 78, 72 | 85, 74, 68 | 53 (42–64) | 58 (49–64) | 516 (433–606) | 16 (11–23) | |||
| Taner et al.37 | 2012 | DCD (n=200) | 92.6, 85.0, 80.9 | 80.9, 72.7, 68.9 | 40.3 ± 16.4 | 55.1 ± 9.4 | 25.3 ± 10.8 | 360 ± 90 | 17.9 ± 7.9 |
| DBD (n=1828) | 89.8, 83.0, 76.6 | 83.3, 75.1, 68.6 | 46.6 ± 19.7 | 54.1 ± 10.4 | 420 ± 114 | 18.5 ± 8.6 | |||
| Vanatta et al.29 | 2013 | DCD (n=38) | 92, 80, - | 92, 74, - | 33 ± 15 | 56 ± 8 | 21 ± 8 | 289 ± 97 | 16 ± 3 |
| DBD (n=76) | 92, 86, - | 91, 85, - | 34 ± 15 | 55 ± 7 | 280 ± 11 | 18 ± 6 | |||
| Doyle et al.74 | 2015 | DCD (n=49) | 95.9, 90.6, 87.1 | 93.6, 86.0, 79.5 | 29.1 ± 12.8 | 56.4 ± 10.4 | 33.6 ± 9.3 | 342 ± 114 | 18.7 ± 7.1 |
| DBD (n=98) | 94.7, 83.5, 80.3 | 92.6, 81.4, 78.1 | 29.9 ± 12.1 | 54.9 ± 65.3 | 342 ± 132 | 18.3 ± 7.3 |
Abbreviations: CIT, cold ischemic time; DBD, donations after brain death; DCD, donation after circulatory (cardiac) death; MELD, model for end-stage liver disease; WIT, warm ischemic time