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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Eur J Pharmacol. 2017 Mar 23;803:130–137. doi: 10.1016/j.ejphar.2017.03.049

Figure 5. COB-141 inhibits Hs578T and MDA-MB-468 cell expression of IL-6.

Figure 5

Hs578T and MDA-MB-468 cells were treated with a range of COB-141 concentrations to determine the dose dependent effect on IL-6 protein secretion (A and B) and mRNA expression (C and D) which allowed estimation of an IC50 value for each. For each study, the dose response was determined in three separate experiments. The results at each dose were averaged for the three experiments. These averages (+/- the S.E.M.) were plotted vs the concentration of COB-141 to arrive at the figures shown. A best fit regression of the data was performed and the IC50 determined from the resulting curves.