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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Eur J Pharmacol. 2017 Mar 23;803:130–137. doi: 10.1016/j.ejphar.2017.03.049

Figure 9. COB-141 inhibits Hs578T and MDA-MB-468 but not MDA-MB-231 cell secretion of IL-8.

Figure 9

Hs578T (A), MDA-MB-468 (B) and MDA-MB-231 (C) cells were treated with a range of COB-141 concentrations to determine the dose dependent effect on IL-8 protein secretion. For each study, the dose response was determined in three separate experiments using ELISA. The results at each dose were averaged for the three experiments. These averages (+/- the S.E.M.) were plotted vs the concentration of COB-141 to arrive at the figures shown. A best fit regression of the data was performed and the IC50 determined from the resulting curves for the Hs578T and MDA-MB-468 cell lines.