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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Nat Microbiol. 2017 May 15;2:17072. doi: 10.1038/nmicrobiol.2017.72

Figure 4. Increased expression and activity of 12-LOX are associated with active tuberculosis in humans.

Figure 4

a-b. ALOX12-promoter luciferase reporter plasmids carrying different alleles at rs3840880 or rs9904779 were transfected into HeLa cells. After 48h, the indicated luciferase activities were quantified. “F/R value” indicates the ratio of Firefly/Renilla luciferase. Values shown as Mean ± SD. **, p<0.001, one-way ANOVA with Tukey's multiple comparison test. c. The concentrations of 12-HETE in the plasma from healthy controls, ‘HC’ (n = 10), latent TB infection, ‘LTBI’ (n = 10), pulmonary tuberculosis, ‘TB’ (n = 20), and subjects suffering from non-TB lung disease, ‘non-TB’ (n = 10) were determined by ELISA. d. 12-HETE levels in the plasma of active TB patients were determined by ELISA at the indicated time points after initiation of anti-TB chemotherapy. e. 12-HETE levels were significantly correlated with the neutrophil counts in the BALF of patients with pulmonary TB, at the time of diagnosis (n=42). The difference among groups were compared by using one-way ANOVA followed by Tukey's multiple comparison test *, p<0.05, **, p<0.001. Pearson's correlation coefficient (r) and P value of correlation (P) are indicated.